Therapeutic Approach for Trigeminal Neuralgia: A Systematic Review

This umbrella review aimed to determine the various drugs used treat trigeminal neuralgia (TN) and evaluate their efficacies as well side effects by surveying previously published reviews. An online search was conducted using PubMed, CRD, EBSCO, Web of Science, Scopus, Cochrane Library with no limits on publication date or patients’ gender, age, ethnicity. Reviews meta-analyses randomized controlled trials pertaining drug therapy for TN, other relevant articles added from reference lists, were evaluated. Rapid reviews, reviews in languages than English, laboratory studies, case reports, series excluded. A total 588 initially collected; 127 full-text evaluated after removing duplicates screening titles abstracts, 11 finally included this study. Except carbamazepine, most had been inadequately studied. Carbamazepine oxcarbazepine continue be first choice medication classical TN. Lamotrigine baclofen can regarded second-line patients not responding first-line having intolerable carbamazepine. Drug combinations baclofen, gabapentin, ropivacaine, tizanidine, pimozide yield satisfactory results improve tolerance treatment. Intravenous lidocaine acute exaggerations botulinum toxin-A refractory cases. Proparacaine, dextromethorphan, tocainide reported inappropriate treating Anticonvulsants are successful managing neuralgia; nevertheless, there have few studies high levels proof, making it challenging compare even combine a statistically useful way. New research drugs, combination therapies, newer formulations, such vixotrigine, is awaited. There conclusive evidence efficacy pharmacological treatment